I need a way to search for inactive ingredients in medications.

Q: Looking for a table to list inactive ingredients in oral contraceptives. Patient needs a gelatin free product.


Answer

There is a database called Dailymed that is free (run by NLM). It includes labels of a significant number of drugs sold in the United States, but not all. It has an advanced search that allows you to search within the ingredients field of each label (https://dailymed.nlm.nih.gov/dailymed/advanced-search.cfm).

Please see the link screen cast on how to search the database https://app.screencast.com/7U8cqD0NNRpCh

 

Just a few additional tips with DailyMed are:
 

  1. Use the Unique Ingredient Identifier UNII code for gelatin (you'll see there's an option to search by code)
    1. To find the UNII for gelatin, go to FDA Inactive Ingredient Search at Inactive Ingredient Search for Approved Drug Products
  2. You can also search contraceptive* (yes asterisk is the wildcard marker in Daily Med) in the indications & usage section. Most of the contraceptives are classified as contraceptive/contraceptives in both the indications & usage section as well as the description.
  3. Place the boolean NOT in the same field with the UNII (like NOT ..... in inactive ingredient unii code)

 

While DailyMed is your best bet but as we know, there's more than 1 way to skin a cat , lol. So if you want to explore, here's another alternative that is a bit more iterative.


1. You'll still use the UNII code for gelatin so find it from FDA Inactive Ingredient dB
2. Go to the FDALabel database (www.fda.gov/science-research/bioinformatics-tools/...
  2a. direct link: nctr-crs.fda.gov/fdalabel/ui/search
3. Search contraceptive* in the Labeling section for indications & usage
4. export results
5. Refine the SAME search by searching it with the UNII code for the inactive ingredient gelatin in the Labeling, Product & Ingredient Identifiers
6. export these results
7. compare the 2 results to identify which contraceptives are NOT in 'set b'
  7b. unfortunately the FDALabel dB only supports AND & OR. Hence the iterative process. lol
8. Anyway could be an interesting experiment to review .

Definitely recommend the DailyMed as it is more efficient but exploring the FDALabel could be an interesting endeavor. Good luck!

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  • Last Updated Apr 25, 2024
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  • Answered By Amy Nadell

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